Further mechanism studies showed that the circulating level of GLP-1 in mice was unaffected by puerarin. We showed that puerarin reduced the body weight gain, normalized blood glucose, and improved glucose tolerance in high-fat diet-induced and db/db diabetic mice. Although the therapeutic implications of the lipogenic actions of GIP are debated, its ability to improve lipid and glucose metabolism is especially evident when paired with the anorexigenic mechanism of GLP-1. Pharmacies should have the ability to review and approve promotional content that references their compounded products. They likely do not need to be conducted according to GLP, but since these studies may be used in support of a PMA or 510k submission, strong quality systems and procedures, including independent QC review of data, are recommended. Rather than applying GLP standards, it is more important that the study be conducted at a facility with an adequate quality unit (including the performance of an independent QC review of the study results). She reviewed 29 years of feeding data covering more than 100 billion animals, from before 1996 when feed was 100 percent non-GMO, until after its introduction when it soared past 90 percent. This study investigated the effect of breakfast omission on within-day subjective ColonBroom appetite control, energy expenditure, substrate utilisation, and appetite hormone profiles, in response to standardised feeding and exercise.