Here, we review the role of GLP-1 and the actions of associated therapies on glucose metabolism, the gut-renal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM. Following the demonstration that intracerebroventricular administration of GLP-1 inhibited food intake in mice and rats, treatment of animals with peripherally administered GLP-1RA was associated with reduction of food intake and weight loss (1). Flint and colleagues examined the effects of acute GLP-1 infusion on sensations of hunger and satiety in healthy human volunteers. These procedures were run using two cohorts of rats, with identical timing and methods between cohorts and all groups represented in each cohort. However, splitting lawsuits into two tracks, the vision loss lawsuit is now called the "Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Non-Arteritic Anterior Ischemic Optic Neuropathy Products Liability Litigation." While it doesn_t exactly roll off the tongue, perhaps it will pave the way for a more efficient resolution. Your customized program will be tailored to your health goals and needs, and Dr. Liz Tateoka will work with you to make positive progress towards your goals while also allowing for fine-tuning of your customized weight loss program.

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